Hasegawa Lab

Contact Information

Department of Environmental Biology, College of Bioscience & Biotechnology, Chubu University
1200 Matsumoto, Kasugai, 487-8501 Japan
+81-568-51-9864
e-mali: hasegawaelegans（at）hotmail.com

Molecular Genetics, Ecology and Evolution of Symbiotic Interactions

Organisms have successfully adapted to a diverse array of biotic and abiotic environments on Earth throughout a substantial period of evolutionary time.

Symbiosis, encompassing “parasitic,” “mutualistic,” and “competition” relationships, represents sophisticated phenotypes that play a vital role in preserving the health and balance of ecosystems.

Human activities have the potential to disrupt the delicate equilibrium of ecosystems, resulting in severe consequences such as the rapid spread of pest outbreaks and species extinctions, leading to devastating problems that extend beyond borders.

Our laboratory is committed to exploring novel phenomena and capabilities that empower organisms to effectively adapt to their environment. In order to comprehend the mechanisms and evolution of these phenomena, we employ molecular genetics. Through our research, we strive to gain fundamental insights into the challenges we’re currently facing.

Members

Koichi HASEGAWA, PhD (Professor)
Nagae SEIYA, PhD (Visiting Scholar)

Graduate Students

Rintaro NORO (D1) JST SPRING
Taiki SUGIYAMA (M2)
Koshiro KAGA (M1)
Ayaka SUGIMOTO (M1)

Undergraduate Students

Yu ISHIGAKI
Naoya ISHIDA
Hayato ISHIDA
Yusei ICHIE
Shun IWASE
Kento OBAYASHI
Koki KATSUNO
Ami NAKAGAITO
Koki HASHIMOTO
Toshiya MIZUTANI

Koki IIDA
Maiko IMAZU
Takahiro EGUCHI
Kaito OYA
Seifu OKAHASHI
Hazuki ODAHARA
Hiroto KATO
Ai TEZUKA
Ryonosuke TOYONAGA
Akihisa HIROTA

Lab Alumni (Postdocs, Master & Ph.D. Students)

Seiya NAGAE
PhD, JST SPRING, Apr 2021 -Mar 2024
Master, Apr 2019 – Mar 2021
Kango ITO
Master, Apr 2021 – Mar 2023
Kosei NAGATO
Master, Apr 2021 – Mar 2023
Masato MIZUKOSHI
  Master, Apr 2021 – Mar 2023
Jans MORFFE (from Instituto de Ecología y Sistemática, Cuba)
  Visiting Scientist, Fellow of the Daiko Foundation, Oct 2021 – May 2022
  JSPS Research Fellow, Apr 2016 – Dec 2016
Hiroki NAGAYA
  Master, Apr 2020 – Mar 2022
Yumeng SHENG
  Master, Apr 2020 – Mar 2022
Takahiro HAMAGUCHI
  PhD, Apr 2018 – Mar 2021
  Master, Apr 2016 – Mar2018
Zhe HOU (From Jiaxing University, China)
  Master, Apr 2019 – Mar 2021
Masamitsu KOTONE
  Master, Apr 2019 – Mar 2021
Yelizaveta CHERNYSH (from Sumy State University, Ukraine)
  Visiting Scientist, Fellow of the MIF, Jul – Oct 2019
Yuto KOIKE
  Master, Apr 2017 – Mar 2019
Daiki SAWANOMUKAI
  Master, Apr 2017 – Mar 2019
Vina MAULIDIA (from Syiah Kuala University, Indonesia)
  Indonesia Scheme Academic Mobility Exchange Program, PhD, Dec 2017- Jun 2018
Yoriko IKUYO
  Research Associate, Apr 2013 – Mar 2018
Sota OZAWA
  PhD, JSPS DC1, Apr 2015 – Mar 2018
   Master, Apr 2013-Mar 2015
Rina SRIWATI (from Syiah Kuala University, Indonesia)
  Visiting Scientist, Dec 2017 – Jan 2018
  Visiting Scientist, Feb 2015 – Aug 2015
Kazuki SATO
  PhD, JSPS DC1, Apr 2014 – Mar 2017
  Master, Apr 2012 – Mar 2014
Cláudia Sofia LEITE VICENTE (from University of Evora, Portugal)
  JSPS Postdoc Research Fellow, Nov 2014 – Nov 2016
  Postdoc, CST Fellow, Sep 2012 – Feb 2014
Akihiro TAYAMACHI
  Master, Apr 2014 – Mar 2016
Ryoji SHINYA
  Postdoc, JSPS SPD, Apr 2012 – Dec 2014

Recent Publications (Selected)

Ikeda, Y., Koike, Y., Shinya, R., Hasegawa, K. (2024) Geographical distribution and phoretic associations of the viviparous nematode Tokorhabditis atripennis with Onthophagus dung beetles in Japan. Journal of Nematology 56 (1), 20240013.

Sugiyama, T., Sawanomukai, D., Nagae, S., Hasegawa, K. (2023) Exploring the pathogenicity of Oscheius sp. KHA501 and its potential in association with entomopathogenic bacteria. Nematological Research 53 (1/2), 1-10.

Zhang, Y., Wang, L.D., Hasegawa, K., Nagae, S., Chen, H.X., Li, L.W., Li, L. (2022) Molecular identification of a new species of Rhigonema (Nematoda: Rhigonematidae) and phylogenetic relationships within the infraorder Rhigonematomorpha. Parasites & Vectors 15, 427.

Duraisamy, K., Amirthalingam, M., Govindhan, T., Kim, J.C., Hasegawa, K., Palanisamy, S. (2022) Fabrication of zinc oxide nanorods using plant latex serum as a green matrix for the sustainable management of root-knot nematodes. Materials Letters 317, 132098.

Nagae, S., Sato, K., Tanabe, T., Hasegawa, K. (2021) Symbiosis of the millipede parasitic nematodes Rhigonematoidea and Thelastomatoidea with evolutionary different origins. BMC Ecology and Evolution 21, 120.

Hamaguchi, T., Sawanomukai, D., Sato, K., Ozawa, S., Kalaiselvi, D., Hasegawa, K. (2020) The insecticidal activity of an entomopathogenic nematode Heterorhabditis bacteriophora and its symbiotic bacterium Photorhabdus luminescens against Periplaneta and Blattella cockroaches. Nematological Research 50 (2), 27-33. 

Hamaguchi, T., Sato, K., Vicente, C.S.L., Hasegawa, K. (2019) Nematicidal actions of the marigold exudate α-terthienyl: oxidative stress-inducing compound penetrates nematode hypodermis. Biology Open 8 (4), bio038646.

Sato, K., Miyata, K., Ozawa, S., Hasegawa, K. (2019) Systemic RNAi of V-ATPase subunit B causes molting defect and developmental abnormalities in Periplaneta fuliginosa. Insect Science 26 (4), 721-731.

Ikuyo, Y., Kabir, F., Ozawa, S., Koike, Y., Ishiguro, H., Hasegawa, K. (2018) Characterisation and pathogenicity of Ditylenchus dipsaci isolated from Phlox subulata in Japan. Nematology 20 (8), 811-814.

Ozawa, S., Hasegawa, K. (2018) Broad infectivity of Leidynema appendiculatum (Nematoda: Oxyurida: Thelastomatidae) parasite of the smokybrown cockroach Periplaneta fuliginosa (Blattodea: Blattidae). Ecology and Evolution 8 (8), 3908-3918.

Morffe, J., Hasegawa, K.(2017) Morphological and molecular characterization of Travassosinema claudiae n. sp. (Oxyuridomorpha: Travassosinematidae) from the Japanese millipede Parafontaria laminata (Attems, 1909) (Polydesmida: Xystodesmidae). Zootaxa 4282 (1), 166-178.

Vicente, C.S.L., Ozawa, S., Hasegawa, K. (2016) Composition of the cockroach gut microbiome in the presence of parasitic nematodes. Microbes and Environments 31 (3), 314-320.

Sato, K., Yoshiga, T., Hasegawa, K. (2016) Involvement of vitamin B6 biosynthesis pathways in the insecticidal activity of Photorhabdus luminescens. Applied and Environmental Microbiology 82 (12), 3546-3553.

Vicente, C.S.L., Nascimento, F.X., Ikuyo, Y., Cock, P.J.A., Mota, M., Hasegawa, K. (2016) The genome and genetics of a high oxidative stress tolerant Serratia sp. LCN16 isolated from the plant parasitic nematode Bursaphelenchus xylophilus. BMC Genomics 17, 301.

Vicente, C.S.L., Ikuyo, Y., Shinya, R., Mota, M., Hasegawa, K. （2015） Catalases induction in high virulence pinewood nematodeBursaphelenchus xylophilusunder hydrogen peroxide-induced stress. PLOS ONE 10 （4）, e0123839.

Nascimento, F.X., Hasegawa, K., Mota, M., Vicente, C.S.L. （2015） Bacterial role in pine wilt disease development – review and future perspectives. Environmental Microbiology Reports 7 （1）, 51-63.

Shinya, R., Hasegawa, K., Chen, A., Kanzaki, N., Sternberg, P. （2014） Evidence of hermaphroditism and sex ratio distortion in the fungal feeding nematode Bursaphelenchus okinawaensis. G3 Genes Genomes Genetics 4 （10）, 1907-1917.

Hino, A., Tanaka, T., Takaishi, M., Fujii, Y., Palomares-Rius, J. E., Hasegawa, K., Maruyama, H., Kikuchi, T. （2014） Karyotype and reproduction mode of the rodent parasite Strongyloides venezuelensis. Parasitology 141 （13）, 1736-1745.

Vicente, C.S.L., Ikuyo, Y., Mota, M., Hasegawa, K. （2013） Pinewood nematode-associated bacteria contribute to oxidative stress resistance of Bursaphelenchus xylophilus. BMC Microbiology13, 299.

Kikuchi, T., Cotton, J. A., Dalzell, J. J., Hasegawa, K., Kanzaki, N., McVeigh, P., Takanashi, T., Tsai, I. J., Aseffa, S. A., Cock, P. J. A., Otto, T. D., Hunt, M., Reid, A. J., Sanchez-Flores, A., Tsuchihara, K., Yokoi, T., Larsson, M. C., Miwa, J., Maule, A. G., Sahashi, N., Jones, J. T. and Berriman, M. （2011） Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus. PLoS Pathogens 7 （9）, e1002219.