応用生物化学科 中川研究室

応用生物化学科 中川研究室TOP

原著論文・著書

2022年

  1. Hagiwara, S., Nishida, N., Ida, H., Ueshima, K., Minami, Y., Takita, M., Aoki, T., Morita, M., Chishina, H., Komeda, Y., Yoshida, A., Park, AM., Sato, M., Kawada, A., Nakano, H., Nakagawa, H., and Kudo, M. (2022) Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria. Sci Rep,12, 6100. 

2021年

  1. Hara, S., Kusunoki, T., Nakagawa, H., Toyoda, Y., Nojiri, S., Kamiya, K., Furukawa, M., Takata, Y., Okada, H., Anzai, T., Matsumoto, F., and Ikeda, K. Association between earwax-determinant genotypes and acquired middle ear cholesteatoma in a Japanese population. Otolaryngol Head Neck Surg, 166, 139-145. 

2019年

  1. Inoue, Y., Morita, T., Onozuka, M., Nakagawa, H., Sano, M., Saito, K., Kondo, M., Yoshida, H., Kishino, T., and Ikegami, Y. (2019) Impact of Q141K on the transport of epidermal growth factor receptor tyrosine kinase inhibitors by ABCG2. Cells, 8, E763.
  2. Ishiguro, J., Ito, H., Tsukamoto, M., Iwata, H., Nakagawa, H., and Matsuo, K. (2019) A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese. Carcinogenesis, 40, 537-543.
  3. Yoshida, M., Adachi, K., Murase, H., Nakagawa, H., and Doi, T. (2019) Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the α-Hydroxycarboxylic Acid Moiety. European J Org Chem., 7, 1669-1676.
  4. Tsukamoto, M., Yamashita, M., Nishi, T., and Nakagawa, H. (2019) A human ABC transporter ABCC4 gene SNP (rs11568658, 559 G>T, G187W) reduces ABCC4-dependent drug resistance. Cells, 8, E39.

2018年

  1. Kusunoki, T., Nakagawa, H., Tsukamoto, M., Toyoda, Y., Kamiya, K., Okada, H., Hara, S., Furukawa, M. and Ikeda, K. (2018) Possible Association between Middle Ear Cholesteatoma and A Single Nucleotide Polymorphism 538G>A in ABCC11, A Human Earwax Type Determinant., J. Mol. Genet. Med., 12, 362-364.
  2. Mitani, Y., Satake, K., Tsukamoto, M., Nakamura, I., Kadioglu, O., Teruya, T., Yonezawa, T., Cha, BY., Efferth, T., Woo, JT., and Nakagawa, H. (2018) Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine, 51, 112-119.
  3. Efferth, T., Banerjee, M., Abu-Darwish, MS., Abdelfatah, S., Böckers, M., Bhakta-Guha, D., Bolzani, V., Daak, S., Demirezer, ÖL., Dawood, M., Efferth, M., El-Seedi, HR., Fischer, N., Greten, HJ., Hamdoun, S., Hong, C., Horneber, M., Kadioglu, O., Khalid, HE., Khalid, SA., Kuete, V., Mahmoud, N., Marin, J., Mbaveng, A., Midiwo, J., Nakagawa, H., Naß, J., Ngassapa, O., Ochwang’I, D., Omosa, LK., Ooko, EA., Özenver, N., Poornima, P., Romero, MR., Saeed, MEM., Salgueiro, L., Seo, EJ., Yan, G., Yasin, Z., Saeed, EM., and Paul, NW. (2018) Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts. Phytomedicine, 11, 30190-30199.
  4. Nakagawa, H., Toyoda, Y., Albrecht, T., Tsukamoto, M., Praetorius, M. Ishikawa, T., Kamiya, K., Kusunoki, T., Ikeda, K., and Sertel, S. (2018). Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Med. Hypotheses. 114, 19-22.

2017年

  1. Kusunoki, T., Nakagawa, H., Tsukamoto, M., Toyoda, Y., Kamiya, K., Okada, H., Hara, S., Hatakeyama, K., Furukawa, M., Ikeda, K. (2017). Earwax Phenotype Related to A Risk Factor of Middle Ear Cholesteatoma. M. J. Othol. 1, 003. 
  2. 中川大, 禹済泰, 永井和夫. (2017). 抗骨粗鬆症. 茶の事典, 朝倉書店, 435-438.
  3. Tsukamoto, M., Sato, S., Satake, K., Miyake, M., and Nakagawa, H.. Quantitative evaluation of drug resistance profile of cells expressing wild-type or genetic polymorphic variants of the human ABC transporter ABCC4. Int. Journal of Molecular Sciences. 18, E1435.  
  4. Toyoda, Y., Takada, T., Gomi, T., Nakagawa, H., Ishikawa, T., and Suzuki, H. (2017). Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis. Int. Journal of Molecular Sciences. 18, E417. 

2016年

  1. Yoshida, M., Sato, H., Murase, H., Nakagawa, H., and Doi, T. (2016). Combinatorial Solid-Phase Synthesis and Biological Evaluation of Cyclodepsipeptide Destruxin B as a Negative Regulator for Osteoclast Morphology. ACS Combinatorial Science. 18, 590-5.
  2. Effert, T., Banerjee, M., Paul, NW., Abdelfatah, S., Arend, J., Elhassan, G., Hamdoun, S., Hamm, R., Hong, C., Kadioglu, O., Naß, J., Ochwangi, D., Ooko, E., Ozenver, N., Saeed, M.E.M., Schneider, M., Seo, EJ., Wu, CF., Yan, G., Zeino, M., Zhao, Q., Abu-Darwish, M.S., Andersch, K., Alexie, G., Bessarab, D., Bhakta-Guha, D., Bolzani, V., Dapat, E., Donenko, F.V., Efferth, M., Greten, HJ., Gunatilaka, L., Hussein, AA., Karadeniz, A., Khalid, HE., Kuete, V., Lee, IS., Liu, L., Midiwo, J., Mora, R.,Nakagawa, H., Ngassapa, O., Noysang, C., Omosa, LK., Roland, FH., Shahat, AA., Saab, A., Saeed, EM., Shan, L., Titinchi, S.J.J. (2016). Biopiracy of natural products and good bioprospecting practice. Phytomedicine, 23, 166-73.
  3. Toyoda, Y., Gomi, T., Nakagawa, H., Nagakura, M., and Ishikawa, T. (2016). Diagnosis of human axillary osmidrosis by genotyping of the human ABCC11 gene: Clinical practice and basic scientific evidence. Biomed Res Int., 7670483.
  4. Fukunaga,K., Nakagawa, H., Ishikawa, T., Kubo, M., and Mushiroda, T. (2016). ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population. BMC Genetics, 17, 79.

2015年

  1. Satake, K., Tsukamoto, M., Mitani, Y., Regasini LO, Bolzani Vda S, Efferth, T., and Nakagawa, H. (2015). Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens. Biomed Mater Eng. 249-256.
  2. Tajima, Y., Murase, H., Satake, K., Mitani, Y., Regasini LO, Bolzani Vda S, Efferth, T., and Nakagawa, H. (2015). Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death. Cytotechnology. 585-592.
  3. Doi, T., Yamaguchi, N., Ohsawa, K., Nakai, K., Yoshida, M., Satake, K., Mitani, Y., Nakagawa, H., Takahashi, T., and Ishikawa, T. (2015). Synthesis and Biological Evaluation of C-Aromataxane Derivatives as P-Glycoprotein-Mediated Multi Drug Resistance Reversal Agents. Heterocycles, 90, 482-501.

2014年

  1. Yoshida, M., Sato, H., Ishida, Y., Nakagawa, H., and Doi, T. (2014). Scalable Solution-Phase Synthesis of Biologically Active Cyclodepsipeptide Destruxin E, a Potent Negative Regulator of Osteoclast Morphology. J. Org. Chem., 296-306.
  2. Satake, K., Toyoda, Y., and Nakagawa, H.　(2014). Drugs affecting epigenetics of ABC transporters for drug resistance. Thomas E., editor. Resistance to Targeted ABC Transporters in Cancer, Resistance to Targeted Anti-Cancer Therapeutics Vol. 4, Springer International Publishing Switzerland, 273-297.
  3. Tajima, Y., Nakagawa, H., Tamura, A., Kadioglu, O., Satake, K., Mitani, Y., Murase, H., Regasini LO, Bolzani Vda S, Ishikawa, T., Fricker, G., and Efferth, T. (2014). Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, 323-332.Tajima, Y. and Nakagawa, H. contributed equally to this work.

2013年

  1. Inoue, Y., Ikegami, Y., Sano, K., Suzuki, T., Yoshida, H., Nakamura, Y., Nakagawa, H., and Ishikawa, T. Gefitinb Enhances the Antitumor Activity of CPT-11 in vitro and in vivo by Inhibiting ABCG2 but not ABCB1: A New Clue to Circumvent Gastrointestinal Toxicity Risk. Chemotherapy, 260-272. 
  2. 中川大.(2013). 遺伝子を構成する分子1つの違いから個人の違いを理解する. ANTENNA, 118, 16
  3. Ishikawa, T., Wakabayashi-Nakao, K., and Nakagawa, H. (2013). Methods to Examine the Impact of Nonsynonymous SNPs on Protein Degradation and Function of Human ABC Transporter. Methods Mol. Biol., 225-250.
  4. Ishikawa, T., Kajimoto, Y., Sun, W., Nakagawa, H., Inoue, Y., Ikegami, Y., Miyatake, S., and Kuroiwa, T. (2013). Role of Nrf2 in Cancer Photodynamic Therapy: Regulation of Human ABC Transporter ABCG2. J. Pharm. Sci., 3058-3069.

2012年

  1. 田島靖浩, 佐竹一紘，塚本めぐみ，村瀬隼人，三谷勇仁，中川大. (2012). 一塩基多型と個人差. 生物機能開発研究所紀要. 13, 69-74.
  2. 浅井みどり, 中川大, 米澤貴之, 車炳允, 大西素子, 永井和夫, 禹済泰. (2012). 閉経後肥満モデルマウスにおけるAurapteneの抗肥満効果. 機能性食品と薬理栄養, 7, 187-195.

2011年

  1. Nakagawa, H., Toyoda, Y., Wakabayashi-Nakao, K., Tamaki, H., Osumi, M., and Ishikawa, T. （2011）. Ubiquitin-mediated proteasomal degradation of ABC transporters: A new aspect of genetic polymorphisms and clinical impacts. J. Pharm. Sci., 100, 3602-3619.
  2. 豊田優, 中川大, 石川智久. （2011）. ABCC11遺伝子の機能. 腋臭症・多汗症治療実践マニュアル, 全日本病院出版会, 123-129.
  3. 中川大, 禹済泰. (2011). カテキン. 機能性食品素材の骨と軟骨への応用, シーエムシー出版, 141-149.
  4. 豊田優, Wanping Aw, Alexander Lezava, 中川大, 林崎良英, 石川智久. （2011）. ヒトABCトランスポーターのファーマコゲノミクス：迅速SNP検出法の開発. 遺伝子医学MOOK, 株式会社メディカルドゥ, 19, 160-167.
  5. 中川大, 豊田優, 中尾（若林）香菜子, 石川智久. （2011）. 小胞体におけるABCトランスポーターの品質管理―ユビキチン-プロテアソーム経路による新生ABCG2蛋白質の除去―. 遺伝子医学MOOK, 株式会社メディカルドゥ, 19, 230-235.

2010年

  1. Ishikawa, T., Nakagawa, H., Hagiya, Y., Nonoguchi, N., Miyatake, S., and Kuroiwa, T. （2010）. Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. Advances in Pharmacological Science, in press.
  2. Wakabayashi-Nakao, K., Tamura, A., Toyoda, Y., Koshiba, S., Nakagawa, H., and Ishikawa, T. （2010）. Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system. Methods Mol. Biol., 648, 139-159.

2009年

  1. Furukawa, T., Wakabayashi, K., Tamura, A., Nakagawa, H., Morishima, Y., Osawa, Y., and Ishikawa, T. （2009）. Major SNP （Q141K） Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations. Pharm. Res., 26, 469-479.
  2. Wakabayashi-Nakao, K., Tamura, A., Furukawa, T., Nakagawa, H., and Ishikawa, T. （2009）. Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation. Advanced Drug Delivery Reviews, 61, 66-72.
  3. Toyoda, Y., Sakurai, A., Mitani, Y., Nakashima, M., Yoshiura, K., Nakagawa, H., Sakai, Y., Lezhava, A., Hayashizaki, Y., Niikawa, N., and Ishikawa, T. （2009）. Earwax, osmidrosis, and breast cancer: Why does one SNP （538G>A） in the human ABC transporter ABCC11 gene determine earwax type? FASEB J., 23, 2001-2013.
  4. Adachi, T., Nakagawa, H., Hagiya, Y., Yasuoka, T., and Ishikawa, T. （2009）. Transport-metabolism interplay: LXRa-mediated induction of human ABC transporter ABCC2 （cMOAT/MRP2） in HepG2 cells. Mol. Pharmaceutics., 6, 1678-1688.
  5. Ishikawa, T. and Nakagawa, H.（2009）. Human ABC Transporter ABCG2 in Cancer Chemotherapy and Pharmacogenomics. J. Exp. Ther. Oncol., 8, 5-24.
  6. Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., and Ishikawa, T. （2009）. Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2. FEBS J., 276, 7237-7252. Selected for the Virtual Issue on Glycosylation.
  7. 萩谷祐一郎, 足立達彦, 小倉俊一郎, 安然, 田村藍, 中川大, 望月徹, 石川智久. （2009）. ポルフィリンの光励起によるヒトABCトランスポーターABCG2とヘムオキシゲナーゼの誘導におけるNrf2の役割. Porphyrins, The Society for Porphyrin Research, 18, 13-17.
  8. 足立達彦, 萩谷祐一郎, 中川大, 石川智久. （2009）. 天然物及び食品添加物による細胞内レドックス制御機構の温故知新. Foods & Food Ingredients J., 214, 35-47.
  9. 中川大. （2009）. 若手研究者インターナショナル・トレーニング・プログラム（ITP）：ハイデルベルク大学派遣報告. 東工大クロニクル, 437, 27-28.

2008年

  1. Nakagawa, H., Tamura, A., Wakabayashi, K., Hoshijima, K., Komada, M., Yoshida, T., Kometani, S., Matsubara, T., Mikuriya, K., and Ishikawa, T. （2008）. Ubiquitin-mediated proteasomal degradation of non-synonymous SNP Variants. Biochemical J., 411, 623-631.
  2. Hagiya, Y., Adachi, T., Ogura, S., An, R., Tamura, A., Nakagawa, H., Okura, I., Mochizuki, T., and Ishikawa, T. （2008）. Nrf2-dependent Induction of Human ABC Transporter ABCG2 and Hemeoxygenase-1 in HepG2 cells by Photoactivation of Porphyrins: Biochemical Implications for Cancer Cell Response to Photodynamic Therapy. J. Exp. Ther. Oncol., 7, 153-167.

2007年

  1. Nakagawa, H., Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, JT., Nagai, K., Ishikawa, T., and Wachi, M. （2007）. Identification of two biologically-crucial hydroxyl groups of （–）-epigallocatechin gallate in osteoclast culture. Biochem. Pharmacol., 73, 34-43.
  2. Adachi, T., Nakagawa, H., Chung, I., Hagiya, Y., Hoshijima, K., Noguchi, N., Kuo, T.M., and Ishikawa, T. （2007）. Nrf2-dependent and -independent Induction of ABC Transporters ABCC1, ABCC2, and ABCG2 in HepG2 Cells under Oxidative Stress. J. Exp. Ther. Oncol., 6, 335-348.  Adachi, T. and Nakagawa, H. contributed equally to this work.
  3. Wakabayashi, K., Nakagawa, H., Tamura, A., Koshiba, S., Hoshijima, K., Komada, M., and Ishikawa, T. （2007）. Intramolecular disulfide bond is a critical checkpoint determining degradative fates of ABC transporter ABCG2 protein.J. Biol. Chem., 282, 27841-27846.
  4. Aida-Hyugaji, S.,Nakagawa, H., Nomura, J., Sakurai, M., Nagashima, U., and Ishikawa, T. （2007）. Theoretical Studies for Molecular Modeling of New Camptothecin Analogues. Croat. Chemica. Acta, 80, 277-281.
  5. Saito, H., Hirano, H., Nakagawa, H., Hoshijima, K., and Ishikawa, T. （2007）. Transport Mechanism-Based Drug Molecular Design: A New Strategy of High-Speed Screening and Quantitative SAR Analysis of ABC Transport ABCG2 to design Novel Anticancer Drugs. Progress in Cancer Drug Resistance Research, Nova Publishers, 43-71.

2006年

  1. Wakabayashi, K., Nakagawa, H., Adachi, T., Kii, I., Kobatake, E., Kudo, A., and Ishikawa, T. （2006）. Cysteine-603 is a critical amino acid for homodimer formation of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system. J. Exp. Ther. Oncol., 5, 205-222.
  2. Ishikawa, T., Ikegami, Y., Sano, K., Nakagawa, H., and Sawada, S. （2006）. Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells. Curr.Pharm. Des., 12, 313-325.
  3. Nakagawa, H., Saito, H., Ikegami, Y., Aida-Hyugaji, S., Sawada, S., and Ishikawa, T. （2006）. Molecular Modeling of New Camptothecin Analogues to Circumvent ABCG2-mediated Drug Resistance in Cancer. Cancer Lett., 234, 81-89.
  4. Woo, JT., Kawatani, M., Kato, M., Shinki, T., Yonezawa, T., Kanoh, N., Nakagawa, H., Takami, M., Lee, K.H., Stern, P.H., Nagai, K., and Osada, H. （2006）. Reveromycin A, a novel agent for osteoporosis inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc. Natl. Acad. Sci. USA., 103, 4729-4734.
  5. Saito, H., Hirano, H., Nakagawa, H., Fukami, T., Oosumi, K., Murakami, K., Kimura, H., Kouchi, T., Konomi, M., Tao, E., Tsujikawa, N., Tarui, S., Nagakura, M., Osumi, M., and Ishikawa, T. （2006）. A New Strategy of High-Speed Screening and Quantitative SAR Analysis To Evaluate Human ABC Transporter ABCG2-Drug Interactions. J. Pharmacol. Exp. Ther., 317, 1114-1124.
  6. Hirano, H., Kurata, A., Onishi, Y., Sakurai, A., Saito, H., Nakagawa, H., Nagakura, M., Tarui, S., Kanamori, Y., Kitajima, M., and Ishikawa, T. （2006）. High-Speed Screening and QSAR Analysis of Human ATP-Binding Cassette Transporter ABCB11 （Bile Salt Export Pump） To Predict Drug-induced Intrahepatic Cholestasis. Mol. Pharmaceutics, 3, 252-265.
  7. Tamura, A., Watanabe, M., Saito, H., Nakagawa, H., Kamachi, T., Okura, I., and Ishikawa, T. （2006）. Functional Validation of The Genetic Polymorphisms of Human ABC Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport. Mol. Pharmacol., 70, 287-296.
  8. Tamura, A., Wakabayashi, K., Onishi, Y., Nakagawa, H., Tsuji, M., Matsuda, Y., and Ishikawa, T. （2006）. Genetic Polymorphisms of Human ABC Transporter ABCG2: Development of the Standard Method for Functional Validation of SNPs by using the Flp Recombinase System. J. Exp. Ther. Oncol., 6, 1-11.
  9. Shirasaka, Y., Onishi, Y., Sakurai, A., Nakagawa, H., Ishikawa, T., and Yamashita, S. （2006）. Evaluation of Human P-Glycoprotein （MDR1/ABCB1） ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements: Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs. Biol. Pharm. Bull., 29, 2465-2471.
  10. Ishikawa, T., Nakagawa, H., and Kuo, T.M. （2006）. The GS-X Pumps/Multidrug Resistance Proteins （MRP） Role of Glutathione in Their Function and Gene Regulation. In: Aiello, Christopher V., editor. Multidrug Resistance-associated Proteins. Multidrug resistance-associated proteins, Nova Publishers, 1-29.
  11. 田村藍, 大西裕子, 渡邉正人, 齊藤光, 中川大, 蒲池利章, 大倉一郎, 石川智久. （2006）. ヒトABCトランスポーターABCG2の遺伝子多型とポルフィリン症のリスク. Porphyrins, The Society for Porphyrin Research, 15, 21-22.
  12. 中川大, 永井和夫. （2006）, 破骨細胞の機能を調節する緑茶成分EGCG.. 茶の効能と応用開発, シーエムシー出版, 196-204.

2005年

  1. Woo, JT., Nakagawa, H., Krecic, K.M., Nagai, K., Hamilton, A.D., Sebti, S.M., and Stern, P.H. （2005）. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor （GGTI-2166） on mononuclear osteoclast formation induced by receptor activator of NFkappaB ligand （RANKL） or tumor necrosis factor-alpha （TNF-α）. Biochem. Pharmacol., 69, 87-95.
  2. Takahashi, T., Nakai, K., Doi, T., Yasunaga, M., Nakagawa, H., and Ishikawa, T. （2005）. Synthesis and Evaluation of 3D Templates Based on a Taxane Skeleton to Circumvent P-glycoprotein-associated Multidrug Resistance of Cancer. Bioorg. Med. Chem. Lett., 15, 2601-2605.
  3. Ishikawa, T., Tamura, A., Saito, H., Wakabayashi, K., and Nakagawa, H.（2005）. Pharmacogenomics of the Human ABC Transporter ABCG2: From Functional Evaluation to Drug Molecular Design. Naturwissenschaften,92, 1-13.
  4. 石川智久, 櫻井亜季, 大西裕子, 中川大. （2005）. 癌の薬剤耐性機構解明から薬物トランスポーター遺伝子多型の臨床診断へ. BIO INDUSTRY, シーエムシー出版, 22, 11-16.

2004年

  1. Woo, JT., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, IS., Ohnishi, M., Hagiwara. H., andNagai, K. （2004）. Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts. Biological Pharm. Bull., 27, 504-509.
  2. Nakagawa, H., Hasumi, K., Woo, JT., Nagai, K., and Wachi, M. （2004）. Generation of hydrogen peroxide primarily contributes to the induction of Fe（II）-dependent apoptosis in Jurkat cells by （–）-epigallocatechin gallate. Carcinogenesis, 25, 1567-1574.

2003年

  1. Nakagawa, H., Takami, M., Udagawa, N., Sawae, Y., Suda, K., Sasaki, T., Takahashi, N., Wachi, M., Nagai, K., and Woo, JT. （2003）. Destruxins, cyclodepsipeptides, block the formation of actin rings, and prominent clear zones and ruffled borders in osteoclasts. Bone, 33, 443-455.

2002年

  1. Nakagawa, H., Wachi, M., Woo, JT., Kato, M., Kasai, S., Takahashi, F., Lee, IS., and Nagai, K. （2002）. Fenton reaction is primarily involved in a mechanism of （-）-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochem. Biophys. Res. Commun., 292, 94-101.